As artificial intelligence reshapes higher education, institutional leaders face pivotal decisions about governance, resource allocation, and academic preparation. This session addresses three critical leadership challenges: establishing governance structures that empower innovation while maintaining institutional oversight, developing compelling investment strategies that secure stakeholder support, and aligning curricula to prepare graduates for an AI-integrated world. Through practical frameworks and case examples, participants will learn how to communicate a clear AI vision, build broad-based support among faculty and boards, and establish their institutions as models for responsible AI innovation.